Expedient route to 3- and 3,3′-substituted 1,1′-bi-2-naphthols by directed ortho metalation and suzuki cross coupling methods

A directed ortho metalation-based route to 3- and 3,3′-substituted binaphthols 2a–c and 3a–c, including chiral materials, is described. Using the Suzuki cross coupling process, dibromo system 3a (E = Br) has been transformed into 3,3′-diaryl binaphthols 5.