甾醇O-酰基转移酶
化学
蒂奥-
微粒体
酶
戒指(化学)
尿素
立体化学
酰基辅酶A
胆固醇
生物化学
有机化学
脂蛋白
作者
Arianna Gelain,Ilaria Bettinelli,Daniela Barlocco,Byoung-Mog Kwon,Tae-Sook Jeong,Kyung-Ran Im,Laura Legnani,Lucio Toma
标识
DOI:10.3797/scipharm.2006.74.85
摘要
A series of N-(2,4-difluorophenyl)-N’-heptyl-N’-{4-[(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate their activity to their structural features.
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