间接运动途径
光遗传学
直接运动途径
中棘神经元
神经科学
纹状体
基底神经节
苍白球
抑制性突触后电位
惩罚(心理学)
心理学
生物
中枢神经系统
多巴胺
发展心理学
作者
Brian R. Isett,Katrina P. Nguyen,Jenna C. Schwenk,Jeff R. Yurek,Christen N. Snyder,Maxime Vounatsos,Kendra Adegbesan,Ugne Ziausyte,Aryn H. Gittis
出处
期刊:Neuron
[Elsevier]
日期:2023-07-01
卷期号:111 (14): 2218-2231.e4
被引量:6
标识
DOI:10.1016/j.neuron.2023.04.017
摘要
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-SPNs) in the striatum drives locomotor suppression and transient punishment, results attributed to activation of the indirect pathway. The sole long-range projection target of A2A-SPNs is the external globus pallidus (GPe). Unexpectedly, we found that inhibition of the GPe drove transient punishment but not suppression of movement. Within the striatum, A2A-SPNs inhibit other SPNs through a short-range inhibitory collateral network, and we found that optogenetic stimuli that drove motor suppression shared a common mechanism of recruiting this inhibitory collateral network. Our results suggest that the indirect pathway plays a more prominent role in transient punishment than in motor control and challenges the assumption that activity of A2A-SPNs is synonymous with indirect pathway activity.
科研通智能强力驱动
Strongly Powered by AbleSci AI