癌症
自噬
维生素
生物
癌细胞
观察研究
癌症预防
氧化应激
生理学
生物信息学
内科学
内分泌学
医学
生物化学
细胞凋亡
遗传学
作者
JoEllen Welsh,Min Ji Bak,Carmen J. Narvaez
标识
DOI:10.1016/j.molmed.2022.07.002
摘要
Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Newly discovered functions of vitamin K in cancer cells include activation of the steroid and xenobiotic receptor (SXR) and regulation of oxidative stress, apoptosis, and autophagy. We provide an update of vitamin K biology, non-canonical mechanisms of vitamin K actions, the potential functions of vitamin K-dependent proteins in cancer, and observational trials on vitamin K intake and cancer.
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