H2O2 Self‐Supplying CaO2/CuO2/Fe3O4 Nanoplatform for Enhanced Chemodynamic Therapy of Cancer Cells

Abstract Due to the properties of hypoxia, lower pH, and higher hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment (TME), a wide variety of metal peroxide nanomaterials have got great attention for efficient TME‐responsive and ‐regulated tumor therapy. However, a single species of metal peroxide is inadequate to realize high effective anticancer therapy. Herein, we have synthesized a hyaluronic acid (HA) modified CaO 2 /CuO 2 /Fe 3 O 4 nanocomposite by a simple and flexible strategy. CaO 2 can generate H 2 O 2 by reacting with water in slightly acidic TME, and the self‐supplying H 2 O 2 can be catalyzed to generate ⋅OH by both Cu 2+ and Fe 2+ via Fenton‐type reaction. Strongly oxidizing ⋅OH can induce tumor cells death for enhanced chemodynamic therapy (CDT). The H 2 O 2 self‐supplying and ⋅OH self‐catalyzed nanocomposite exhibited favorable pH‐controlled ⋅OH generation and excellent cancer cells growth inhibition ability, providing a potential nanotheranostics platform with active targeting and favorable therapeutic efficacy in tumor therapy.