均分解
化学
钛
群(周期表)
乙醚
立体化学
药物化学
光化学
有机化学
激进的
作者
Tetsuya Suga,Ryusei Takada,Masaya Sakamoto,Yutaka Ukaji
标识
DOI:10.1021/acs.orglett.4c00590
摘要
Ether C–O bonds are typical constituents of organic molecules that are seldom regarded as reactive functional groups except when highly strained. With the assistance of appropriate directing groups, low-valent titanium was found to homolytically cleave non-strained C–O bonds. In particular, a newly designed catechol monoether directing group rendered a route toward the activation of non-benzylic C(sp3)–O bonds. This method has been applied to conventional radical addition reactions to alkenes.
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