阻塞性睡眠呼吸暂停
医学
持续气道正压
血脂异常
肥胖
心情
共病
生活质量(医疗保健)
2型糖尿病
睡眠呼吸暂停
糖尿病
睡眠障碍
物理疗法
内科学
失眠症
精神科
内分泌学
护理部
作者
Emily J. Meyer,Gary Wittert
标识
DOI:10.1210/clinem/dgad572
摘要
Obstructive sleep apnoea (OSA) and obesity are highly prevalent and bidirectionally associated. OSA is however underrecognized, particularly in women. By mechanisms that overlap with those of obesity, OSA increases the risk of developing, or having poor outcomes from, comorbid chronic disorders and impairs quality of life. Using two illustrative cases we discuss the relationships between OSA and obesity with type 2 diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, and reproductive disorders. The differences in OSA between men and women, the phenotypic variability of OSA, and co-morbid sleep disorders are highlighted. When the probability of OSA is high due to consistent symptoms, comorbidities, or both, a diagnostic sleep study is advisable. Continuous positive airway pressure or mandibular advancement splints improve symptoms. Benefits for comorbidities are variable depending on nightly duration of use. By contrast weight loss and optimization of lifestyle behaviors are consistently beneficial.
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