Recent Advances in the Photocatalytic Defluorinative Functionalization of Trifluoromethyl Arenes and Trifluoromethyl Ketones via Radical Process

Abstract Recent years have witnessed rapid growth in the C─F bond functionalization of trifluoromethyl arenes and trifluoromethyl carbonyl compounds, which has been promoted by the development of photoredox catalysis. In this review, the photocatalyzed C─F bond activation of trifluoromethyl arenes and trifluoromethyl carbonyl compounds via difluoromethyl radical intermediate has been covered. This review was categorized into three parts based on the activation modes of C─F bond. Several representative instances, in conjunction with the reaction mechanism, were also deliberated upon.