Nanoigniter-Integrated Microneedle Patches for Boosted Photothermal-Mediated Multimodal Therapy: In Situ Tumor Microenvironment Igniting Strategy

, which efficiently helps LOX in catalyzing FFAs to promote lipid peroxide generation and induce tumor ferroptosis. Subsequently, the release of tumor-associated antigens promotes tumor-associated macrophages toward the M1 phenotype and stimulates dendritic cell maturation, thereby activating antitumor immune responses. Consequently, the proposed system established a PTT/ferroptosis/immunotherapy multimodal therapy to form a positive feedback loop of tumor-killing, demonstrating significant antitumor efficacy. Our research provides a versatile framework for leveraging EMH to enhance photothermal-mediated multimodal therapy.