CREBBP Alterations are Associated with A Poor Prognosis in de novo AML

Letter to Blood| April 27, 2023 CREBBP alterations are associated with a poor prognosis in de novo AML Adam J. Lamble, Adam J. Lamble 1Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Kohei Hagiwara, Kohei Hagiwara 2Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN Search for other works by this author on: This Site PubMed Google Scholar Robert B. Gerbing, Robert B. Gerbing 3Children's Oncology Group, Monrovia, CA Search for other works by this author on: This Site PubMed Google Scholar Jenny L. Smith, Jenny L. Smith 4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Pandurang Kolekar, Pandurang Kolekar 2Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN https://orcid.org/0000-0003-0044-0076 Search for other works by this author on: This Site PubMed Google Scholar Rhonda E. Ries, Rhonda E. Ries 4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Edward A. Kolb, Edward A. Kolb 5Division of Oncology, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE Search for other works by this author on: This Site PubMed Google Scholar Todd A. Alonzo, Todd A. Alonzo 3Children's Oncology Group, Monrovia, CA6Keck School of Medicine, University of Southern California, Los Angeles, CA Search for other works by this author on: This Site PubMed Google Scholar Xiaotu Ma, Xiaotu Ma 2Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN Search for other works by this author on: This Site PubMed Google Scholar Soheil Meshinchi Soheil Meshinchi 4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Blood (2023) 141 (17): 2156–2159. https://doi.org/10.1182/blood.2022017545 Article history Submitted: June 24, 2022 Accepted: January 4, 2023 First Edition: January 12, 2023 Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Adam J. Lamble, Kohei Hagiwara, Robert B. Gerbing, Jenny L. Smith, Pandurang Kolekar, Rhonda E. Ries, Edward A. Kolb, Todd A. Alonzo, Xiaotu Ma, Soheil Meshinchi; CREBBP alterations are associated with a poor prognosis in de novo AML. Blood 2023; 141 (17): 2156–2159. doi: https://doi.org/10.1182/blood.2022017545 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Myeloid Neoplasia, Pediatric Hematology TO THE EDITOR: The cyclic adenosine monophosphate response element-binding protein (CREBBP) gene is located on chromosome 16p13 and encodes a histone acetyltransferase having the same name that is involved in transcriptional regulation and cell cycle control.1,2 The translocation t(8;16)(p11;p13)[KAT6A::CREBBP] results in the disruption of CREBBP as well as its fusion to KAT6A, another gene important in transcription control. This fusion is sufficient for leukemogenesis and leads to a rare but well described type of acute myeloid leukemia (AML) with consistent biologic characteristics and a distinct gene expression profile.3-8 Although generally associated with inferior outcomes among adults, including a recent adjustment made by the European LeukemiaNet toward the adverse-risk group, there are variable reports regarding the prognostic significance of this fusion among pediatric patients.4,7,9 This prognostic variability is partially... References 1.Chan HM, La Thangue NB. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci. 2001;114(Pt 13):2363-2373.Google Scholar 2.Shiama N. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell Biol. 1997;7(6):230-236.Google ScholarCrossrefSearch ADS PubMed 3.Camos M, Esteve J, Jares P, et al. 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Cancer Discov. 2020;10(3):440-459.Google ScholarCrossrefSearch ADS PubMed © 2023 by The American Society of Hematology2023 © 2023 by The American Society of Hematology2023 You do not currently have access to this content. Sign in via your Institution