Despite growing awareness of the risks associated with occupational fatigue, healthcare systems continue to rely on fragmented, informal, and largely individual approaches to fatigue management. In contrast to other high-risk industries, healthcare has yet to embed fatigue management within formal safety governance structures. Advancing practice in this area requires a shift towards system-level thinking that is supported by organisational leadership, effective fatigue monitoring, and workforce education. Additionally, this shift also demands a cultural reorientation that recognises fatigue as a predictable and manageable safety risk that necessitates organisational accountability rather than individual resilience to prioritise both staff wellbeing and patient safety.