免疫系统
对策
骨骼肌
再生(生物学)
心肌细胞
干细胞
神经科学
医学
免疫学
心理学
生物
生物信息学
细胞生物学
内科学
工程类
航空航天工程
作者
Helena Slaets,Lena Fonteyn,Bert O. Eijnde,Niels Hellings
标识
DOI:10.1016/j.bbi.2023.03.006
摘要
Frailty and a failing immune system lead to significant morbidities in the final years of life and bring along a significant burden on healthcare systems. The good news is that regular exercise provides an effective countermeasure for losing muscle tissue when we age while supporting proper immune system functioning. For a long time, it was assumed that exercise-induced immune responses are predominantly mediated by myeloid cells, but it has become evident that they receive important help from T lymphocytes. Skeletal muscles and T cells interact, not only in muscle pathology but also during exercise. In this review article, we provide an overview of the most important aspects of T cell senescence and discuss how these are modulated by exercise. In addition, we describe how T cells are involved in muscle regeneration and growth. A better understanding of the complex interactions between myocytes and T cells throughout all stages of life provides important insights needed to design strategies that effectively combat the wave of age-related diseases the world is currently faced with.
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