Copper‐Catalyzed Synthesis of O/N‐Alkyl S‐Phenyl Phenylcarbamothioates: An Odorless and Chemo‐selective Chan–Lam Reaction to Construct C−S Bond

Abstract A simple and efficient synthetic method to C−S bonds was established based on the Chan–Lam reaction. A series of O/N ‐alkyl S ‐phenyl phenylcarbamothioates were obtained in good yields by using odorless O/N ‐alkyl phenylthiocarbamates as sulfur sources and commercially available phenylboronic acids as substrates catalyzed by Cu(OAc) 2 . This methodology features simple performance, odorless sulfur source, easily available starting material, good functional group tolerance, and high chemo‐selectivity to construct C−S bonds, thereby providing an alternative way to the synthesis of potentially bioactive compounds.