Deep learning and radiomics analysis for prediction of placenta invasion based on T2WI

The purpose of this study was to explore whether the Nomogram, which was constructed by combining the Deep learning and Radiomic features of T2-weighted MR images with Clinical factors (NDRC), could accurately predict placenta invasion. This retrospective study included 72 pregnant women with pathologically confirmed placenta invasion and 40 pregnant women with normal placenta. After 24 gestational weeks, all participants underwent magnetic resonance imaging. The uterus and placenta regions were segmented in magnetic resonance images on sagittal T2WI. Ninety-three radiomics features were extracted from the placenta region, and 128 deep features were extracted from the uterus region using a deep neural network. The least absolute shrinkage and selection operator (LASSO) algorithm was used to filter these 221 features and to form the combined signature. Then the combined signature (CS) and clinical factors were combined to construct a nomogram. The accuracy, sensitivity, specificity and AUC of the nomogram were compared with four machine learning methods. The model NDRC was trained on the dataset of 78 pregnant women in the training cohort. Finally, the model NDRC was compared with four machine learning methods on the independent validation cohort of 34 pregnant women. The results showed that the prediction accuracy, sensitivity, specificity and AUC of the NDRC model were 0.941, 0.952, 0.923 and 0.985 respectively, which outperforms the traditional machine learning methods which rely on radiomics features and deep learning features alone.