姐妹染色单体
生物
遗传学
生殖系
染色单体
姐妹染色单体交换
黑腹果蝇
姐妹染色单体结合力的建立
基因组不稳定性
核糖体DNA
修女
粘蛋白
减数分裂
DNA
染色体
DNA损伤
基因
系统发育学
社会学
人类学
作者
George J. Watase,Yukiko M. Yamashita
标识
DOI:10.1126/sciadv.abo4443
摘要
Although considered to be exact copies of each other, sister chromatids can segregate nonrandomly in some cases. For example, sister chromatids of the X and Y chromosomes segregate nonrandomly during asymmetric division of male germline stem cells (GSCs) in Drosophila melanogaster . Here, we demonstrate that the ribosomal DNA (rDNA) loci, which are located on the X and Y chromosomes, and an rDNA binding protein Indra are required for nonrandom sister chromatid segregation (NRSS). We provide the evidence that NRSS, following unequal sister chromatid exchange, is a mechanism by which GSCs recover rDNA copy number, counteracting the spontaneous copy number loss that occurs during aging. Our study reveals an unexpected role for NRSS in maintaining germline immortality through maintenance of a vulnerable genomic element, rDNA.
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