Suzuki–Miyaura Coupling Reactions of Fluorohalobenzenes

Abstract Organofluorine compounds have gained interest in the fields of pharmaceuticals, agrochemicals, diagnostics, materials, and catalysis. Suzuki–Miyaura coupling reactions of fluorinated arenes made a tremendous impact in chemical and biological research and made organofluorinated molecules more readily available. This review gives a brief summary of Suzuki–Miyaura coupling reactions of fluorinated benzene derivatives. In this context, various aspects, such as regio­selectivity, efficiency, and applications, are discussed. 1 Introduction 2 Organofluorine Compounds 3 Suzuki–Miyaura Reactions of Fluorohalobenzenes 3.1 Fluorophthalates 3.2 Reactions of Pentafluorohalobenzenes 3.3 Tetrafluorohalobenzenes 3.4 Trifluorohalobenzenes 3.5 Difluorohalobenzenes 3.6 Monofluorohalobenzenes 3.7 Halo(trifluoromethyl)benzenes 3.8 Trifluoromethyl Pyridines 4 S Summary