Chrysoeriol Attenuates Cisplatin Induced Acute Kidney Injury in A Rat Model by Regulating PI3K/AKT and NF-κB Pathways

Chrysoeriol is a flavonoid with anti-inflammatory and antioxidant capacities against inflammatory diseases. Inflammation and apoptosis participate in the pathogenesis of cisplatin-induced nephrotoxicity. The role of chrysoeriol on acute kidney injury in a cisplatin induced rat model was investigated in this study. An evaluation of the effect of chrysoeriol on cisplatininduced nephrotoxicity by measuring histopathological changes and proinflammatory biomarkers revealed activation of PI3K/AKT and inactivation of NF-κB pathways in the reno-protection by chrysoeriol.