铜绿假单胞菌
羧苄青霉素
阿兹屈南
亚精胺
替卡西林
微生物学
抗生素
化学
氨基糖苷
精胺
多胺
内酰胺
头孢他啶
生物
细菌
庆大霉素
生物化学
立体化学
酶
遗传学
标识
DOI:10.1096/fasebj.26.1_supplement.541.1
摘要
Pseudomonas aeruginosa is a human pathogen causing a variety of diseases. Treatment of P. aeruginosa infections use β‐lactam and aminoglycoside antibiotics; however, the treatment is difficult due to multidrug resistant P. aeruginosa. Polyamines (spermidine and spermine) are cationic compounds and known as enhancing antibiotic susceptibility. In this study, polyamine effects on growth of P. aeruginosa and β‐lactam susceptibility were examined. Results showed that polyamines were non‐toxic on growth of P. aeruginosa and significantly enhanced β‐lactam susceptibility, suggesting polyamines may be used to treat multidrug resistant P. aeruginosa infections in combining with existing β‐lactam antibiotics such as Aztreonam, Carbenicillin, Ceftriaxone, and Ticarcillin.
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