纳米载体
癌症治疗
细胞
膜
细胞外小泡
药物输送
纳米技术
细胞外
细胞膜
癌细胞
胞外囊泡
小泡
生物物理学
外体
材料科学
肿瘤微环境
脂质体
癌症
癌症研究
靶向给药
细胞生物学
纳米医学
纳米颗粒
毒品携带者
体内
细胞毒性
内吞作用
细胞内
化学
医学
生物化学
生物
内科学
作者
Aixue Li,Yunan Zhao,Yixiu Li,Liangdi Jiang,Yongwei Gu,Jiyong Liu
出处
期刊:Drug Delivery
[Informa]
日期:2021-06-18
卷期号:28 (1): 1237-1255
被引量:28
标识
DOI:10.1080/10717544.2021.1938757
摘要
Nanotechnology provides synthetic carriers for cancer drug delivery that protect cargos from degradation, control drug release and increase local accumulation at tumors. However, these non-natural vehicles display poor tumor targeting and potential toxicity and are eliminated by the immune system. Recently, biomimetic nanocarriers have been widely developed based on the concept of 'mimicking nature.' Among them, cell-derived biomimetic vehicles have become the focus of bionics research because of their multiple natural functions, such as low immunogenicity, long circulation time and targeting ability. Cell membrane-coated carriers and extracellular vesicles are two widely used cell-based biomimetic materials. Here, this review summarizes the latest progress in the application of these two biomimetic carriers in targeted cancer therapy. Their properties and performance are compared, and their future challenges and development prospects are discussed.
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