血管内皮生长因子
胚胎
植入失败
子宫内膜
血管生成
血管内皮生长因子A
医学
生物
男科
血管内皮生长因子受体
内科学
细胞生物学
不育
怀孕
遗传学
作者
Xi Guo,Hong Yi,Tin‐Chiu Li,Yu Wang,Huilin Wang,Xiaoyan Chen
出处
期刊:Biomolecules
[MDPI AG]
日期:2021-02-10
卷期号:11 (2): 253-253
被引量:56
摘要
Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.
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