化学
透视图(图形)
范围(计算机科学)
药物发现
功能群
组合化学
纳米技术
有机化学
生物化学
计算机科学
人工智能
材料科学
程序设计语言
聚合物
作者
Patrick Mäder,Lars Kattner
标识
DOI:10.1021/acs.jmedchem.0c00960
摘要
Sulfoximines have been largely disregarded in medicinal chemistry for a long time. However, recently, they have risen to the apparent level of stardom on the drug discovery scene. Considering the outstanding properties of sulfoximines, this versatile functional group has advanced to implementation in several drug discovery programs. Currently, this fashionable functional group can be found in various hit-to-lead and lead optimization studies in early stages and in several compounds currently in clinical trials. Herein, we review recent developments to demonstrate the scope and limitations of this interesting and versatile functional group in medicinal chemistry and drug discovery.
科研通智能强力驱动
Strongly Powered by AbleSci AI