医学
甲状腺癌
甲状腺乳突癌
V600E型
突变
内科学
回声
甲状腺癌
活检
甲状腺
病理
肿瘤科
超声科
放射科
基因
化学
生物化学
作者
Zhi-yan Luo,Yanjun Hong,Qing Wen,Caoxin Yan,Huifang Weng,Guoqiang Mo
标识
DOI:10.3760/cma.j.issn.1004-4477.2016.09.012
摘要
Objective
To evaluate the association of the BRAF V600E mutation with sonographic features in patients with papillary thyroid carcinoma.
Methods
A consecutive series of 61 papillary thyroid carcinoma(PTC) was evaluated by US and elastography before US-FNA, BRAF V600E mutation and surgery.The PTCs were categorized into 2 groups according to the results of the BRAF V600E mutation, BRAF-positive and BRAF-negative patients. The sonographic features were compared between BRAF-positive and BRAF-negative patients.
Results
The BRAF V600E mutation was detected in 82% of patients (50 of 61). There were no significant difference between BRAF-positive and BRAF-negative PTC on sonographic features including the nodular size, echogenicity, shape, margin, calcification and the pattern of blood flow.However the prevalence of PTC with a score higher than 4 on the Hong et al score was 72% (36/50) in the BRAF-positive group, significantly higher than 36.4%(4/11) in the BRAF-negative group(P=0.024). A score higher than 4 correlated highly with a BRAF-positive diagnosis (sensitivity 72.0%, specificity 63.6%, positive predictive value 90.0%, negative predictive value 33.3%, accuracy 70.5% and OR 4.5).
Conclusions
The BRAF V600E mutation was significantly associated with elastography classification, a score higher than 4 on the Hong et al score could highly predict the occurrence of BRAF V600E mutation in papillary thyroid cancer.
Key words:
Ultrasonography; Thyroid neoplasms; Biopsy, fine-needle; BRAF V600E mutation
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