脂肪生成
线粒体
自噬
肿瘤进展
多不饱和脂肪酸
肿瘤微环境
生物
癌症
癌细胞
细胞生物学
脂质代谢
生物信息学
细胞凋亡
生物化学
脂肪酸
遗传学
作者
Alfonso Varela-López,Laura Vera-Ramírez,Francesca Giampieri,María D. Navarro-Hortal,Tamara Y. Forbes‐Hernández,Maurizio Battino,José L. Quiles
标识
DOI:10.1016/j.semcancer.2021.01.001
摘要
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De novo lipogenesis is an important source of lipids for cancer cells, but exogenous lipid uptake remains essential for many cancer cells. Dietary lipids can modify lipids present in tumor microenvironment affecting cancer cell metabolism. Clinical trials have shown that diets rich in polyunsaturated fatty acids (PUFA) can negatively affect tumor growth. However, certain n-6 PUFAs can also contribute to cancer progression. Identifying the molecular mechanisms through which lipids affect cancer progression will provide an opportunity for focused dietary interventions that could translate into the development of personalized diets for cancer control. However, the effective mechanisms of action of PUFAs have not been fully clarified yet. Mitochondria controls ATP generation, redox homeostasis, metabolic signaling, apoptotic pathways and many aspects of autophagy, and it has been recognized to play a key role in cancer. The purpose of this review is to summarize the current evidence linking dietary lipids effects on mitochondrial aspects with consequences for cancer progression and the molecular mechanisms that underlie this association.
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