生发中心
生物
BCL6公司
脾脏
B细胞
淋巴系统
等离子体电池
亲和力成熟
抗体
免疫学
细胞生物学
派尔斑
作者
Adi Biram,Eitan Winter,Alice E. Denton,Irina Zaretsky,Bareket Dassa,Mats Bemark,Michelle A. Linterman,Gur Yaari,Ziv Shulman
出处
期刊:Cell Reports
[Elsevier]
日期:2020-02-01
卷期号:30 (6): 1910-1922.e5
被引量:15
标识
DOI:10.1016/j.celrep.2020.01.032
摘要
Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell functions; however, it is not known whether this mechanism plays a similar role in mucosal-associated lymphoid tissues. Here, we find that in Peyer’s patches (PPs), SAP-mediated T cell help is required for promoting B cell selection in GCs, but not for clonal diversification. PPs of SAP-deficient mice host chronic GCs that are absent in T cell-deficient mice. GC B cells in SAP-deficient mice express AID and Bcl6 and generate plasma cells in proportion to the GC size. Single-cell IgA sequencing analysis reveals that these mice host few diversified clones that were subjected to mild selection forces. These findings demonstrate that T cell-derived help to B cells in PPs includes SAP-dependent and SAP-independent functions.
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