胰岛素
苯硼酸
葡萄糖氧化酶
胰岛素释放
药物输送
化学
小泡
超分子化学
糖尿病
体内
内科学
生物化学
医学
内分泌学
生物传感器
1型糖尿病
有机化学
生物
分子
催化作用
生物技术
膜
作者
Yonghui Lin,Wei Hu,Xiaowen Bai,Yanshan Ju,Cong Cao,Shufen Zou,Zaizai Tong,Chao Cen,Guohua Jiang,Xiangdong Kong
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2020-08-17
卷期号:3 (9): 6376-6383
被引量:19
标识
DOI:10.1021/acsabm.0c00813
摘要
Smart insulin delivery platforms having the ability of mimicking pancreatic cells are highly expected for diabetes treatment. Herein, a smart glucose-sensitive insulin delivery platform on the basis of transcutaneous microneedles has been designed. The as-prepared microneedles are composed of glucose- and pH-responsive supramolecular polymer vesicles (PVs) as the drug storage and water soluble polymers as the matrix. The well-defined PVs are constructed from the host-guest inclusion complex between water-soluble pillar[5]arene (WP5) with pH-responsiveness and paraquat-ended poly(phenylboronic acid) (PPBA-G) with glucose-sensitivity. The drug-loaded PVs, including insulin and glucose oxidase (GOx) can quickly respond to elevated glucose level, accompanied by the disassociation of PVs and fast release of encapsulated insulin. Moreover, the insulin release rate is further accelerated by GOx, which generates gluconic acid at high glucose levels, thus decreasing the local pH. Therefore, the host-guest interaction between WP5 and PPBA-G is destroyed and a total structure disassociation of PVs takes place, contributing to a fast release of encapsulated insulin. The in vivo insulin delivery to diabetic rats displays a quick response to hyperglycemic levels and then can fast regulate the blood glucose concentrations to normal levels, which demonstrates that the obtained smart insulin device has a highly potential application in the treatment of diabetes.
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