抗辐射性
缺氧(环境)
放射治疗
癌症研究
转移
肿瘤微环境
医学
癌症
生物
生物信息学
肿瘤科
内科学
肿瘤细胞
化学
有机化学
氧气
作者
Wafa Bouleftour,Elise Rowinski,Safa Louati,Sandrine Sotton,Anne-Sophie Wozny,Pablo Moreno‐Acosta,Benoîte Méry,Claire Rodriguez-Lafrasse,Nicolas Magné
出处
期刊:Medical Science Monitor
[International Scientific Information, Inc.]
日期:2021-10-05
卷期号:27
被引量:29
摘要
Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be involved in both metastasis initiation and therapy resistance. Radiotherapy is the appropriate treatment in about half of all cancers, but loco-regional control failure and a disease recurrence often occur due to clinical radioresistance. Hypoxia induces radioresistance through a number of molecular pathways, and numerous strategies have been developed to overcome this. Nevertheless, these strategies have resulted in disappointing results, including adverse effects and limited efficacy. Additional clinical studies are needed to achieve a better understanding of the complex hypoxia pathways. This review presents an update on the mechanisms of hypoxia in radioresistance in solid tumors and the potential therapeutic solutions.
科研通智能强力驱动
Strongly Powered by AbleSci AI