精确肿瘤学
转化研究
计算生物学
疾病
精密医学
基因组学
仿形(计算机编程)
抗癌药物
药物发现
癌症
生物信息学
医学
数据科学
计算机科学
生物
生物技术
内科学
基因组
病理
遗传学
操作系统
基因
作者
Oriol Pich,Chris Bailey,Thomas B.K. Watkins,Simone Zaccaria,Mariam Jamal‐Hanjani,Charles Swanton
出处
期刊:Cancer Cell
[Elsevier]
日期:2022-05-01
卷期号:40 (5): 458-478
被引量:28
标识
DOI:10.1016/j.ccell.2022.04.002
摘要
The translational challenges in the field of precision oncology are in part related to the biological complexity and diversity of this disease. Technological advances in genomics have facilitated large sequencing efforts and discoveries that have further supported this notion. In this review, we reflect on the impact of these discoveries on our understanding of several concepts: cancer initiation, cancer prevention, early detection, adjuvant therapy and minimal residual disease monitoring, cancer drug resistance, and cancer evolution in metastasis. We discuss key areas of focus for improving cancer outcomes, from biological insights to clinical application, and suggest where the development of these technologies will lead us. Finally, we discuss practical challenges to the wider adoption of molecular profiling in the clinic and the need for robust translational infrastructure.
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