传感器
生物医学工程
超声波
声学
脉搏(音乐)
腐蚀
脉冲持续时间
超声波传感器
脉冲重复频率
超声波能量
材料科学
光学
医学
放射科
地质学
物理
古生物学
激光器
雷达
电信
探测器
计算机科学
作者
Zhen Xu,Achi Ludomirsky,Lucy Youngmin Eun,Timothy L. Hall,B.C. Tran,J. Brian Fowlkes,Charles A. Cain
出处
期刊:IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
[Institute of Electrical and Electronics Engineers]
日期:2004-06-01
卷期号:51 (6): 726-736
被引量:18
标识
DOI:10.1109/tuffc.2004.1304271
摘要
The ability of ultrasound to produce highly controlled tissue erosion was investigated. This study is motivated by the need to develop a noninvasive procedure to perforate the neonatal atrial septum as the first step in treatment of hypoplastic left heart syndrome. A total of 232 holes were generated in 40 pieces of excised porcine atrial wall by a 788 kHz single-element transducer. The effects of various parameters [e.g., pulse repetition frequency (PRF), pulse duration (PD), and gas content of liquid] on the erosion rate and energy efficiency were explored. An Isppa of 9000 W/cm/sup 2/, PDs of 3, 6, 12, and 24 cycles; PRFs between 1.34 kHz and 66.7 kHz; and gas saturation of 40-55% and 79-85% were used. The results show that very short pulses delivered at certain PRFs could maximize the erosion rate and energy efficiency. We show that well-defined perforations can be precisely located in the atrial wall through the controlled ultrasound tissue erosion (CUTE) process. A preliminary in vivo experiment was conducted on a canine subject, and the atrial septum was perforated using CUTE.
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