低氧血症
耐火材料(行星科学)
体外膜肺氧合
充氧
医学
重症监护医学
氧气输送
按需
急性呼吸窘迫综合征
肺
麻醉
氧气
计算机科学
内科学
材料科学
化学
有机化学
复合材料
多媒体
作者
Ashwin Kumar Vutha,Ryan Patenaude,Alexis R. Cole,Rajesh Kumar,John N. Kheir,Brian D. Polizzotti
标识
DOI:10.1073/pnas.2115276119
摘要
Significance The treatment of hypoxemia that is refractory to the current standard of care is time-sensitive and requires skilled caregivers and use of specialized equipment (e.g., extracorporeal membrane oxygenation). Most patients experiencing refractory hypoxemia will suffer organ dysfunction, and death is common in this cohort. Here, we describe a new strategy to stabilize and support patients using a microfluidic device that administers oxygen gas directly to the bloodstream in real time and on demand using a process that we call sequential shear-induced bubble breakup. If successful, the described technology may help to avoid or decrease the incidence of ventilator-related lung injury from refractory hypoxemia.
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