瓶颈
遗传增强
比例(比率)
生物技术
产品(数学)
模式
过程(计算)
生产(经济)
计算机科学
计算生物学
基因
生物
遗传学
经济
数学
社会科学
嵌入式系统
社会学
宏观经济学
物理
操作系统
几何学
量子力学
作者
Jenny Shupe,An Zhang,Daniel C Odenwelder,Terrence M. Dobrowsky
标识
DOI:10.1016/j.copbio.2022.102721
摘要
Gene therapy is designed to cure various diseases resulting from genetic defects. Currently, recombinant adeno-associated viral vectors (rAAV) are the vehicles of choice for therapeutic gene delivery in vivo. To date, manufacturing sufficient rAAV product to meet rapidly expanding clinical demand remains a bottleneck in the industry. In the past decade, multiple production platforms have been rapidly implemented with encouraging improvements in productivity and scalability. In this review, we discuss the advantages and limitations of the most popular production platforms in the industry with a focus on the cell culture process scale-up.
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