Recent Progress in Natural Anticancer Agents Discovery from Tea (Camellia sinensis): A Review

山茶 多酚 绿茶 咖啡因 传统医学 茶黄素 多糖 茶氨酸 化学 药理学 生物 生物化学 食品科学 医学 植物 抗氧化剂 内分泌学
作者
Jie Zhou,Ruilin Li,Yongxing Jia,Yajie Wang,Junyu Liu,Pharkphoom Panichayupakaranant,Hạixia Chen
出处
期刊:Recent Patents on Anti-cancer Drug Discovery [Bentham Science]
卷期号:17 (4): 343-357 被引量:5
标识
DOI:10.2174/1574892816666211208155811
摘要

Tea, as the bud from the plant Camellia sinensis, is the most consumed popular beverage just next to water; especially green tea has gained much attention because of its health effects. The anticancer effects of tea components including tea polyphenols, in particular epigallocatechin gallate and tea polysaccharides, are widely investigated in recent years.Based on the articles and patents published in the last 10 years, this review focuses on the structural activities and molecular mechanisms of the anticancer effects of tea components (mainly tea polyphenols and tea polysaccharides) to provide references for future anticancer studies of tea.In the database, a literature search was conducted with "tea polyphenols", "tea polysaccharides", "theanine" and "anticancer" as the keywords, and the limited time range was "2010-2021". After sorting out and analyzing the retrieval results, the structure, activity and molecular mechanism, as well as the research progress on the structural modification, drug delivery system and toxicology of natural agents in tea in recent years, were summarized.We found that the natural anticancer agents in tea mainly include tea polyphenols, tea polysaccharides, theanine, caffeine and other components by summarizing the literature. The anticancer mechanisms can be divided into the induction of cell apoptosis, inhibition of cell proliferation, metastasis and invasion, and inhibition of angiogenesis. In the past 10 years, there was little literature on the structural modification, drug delivery system and toxicological evaluation of natural anticancer agents in tea, and there were reports of novel research on nano preparations. The studies showed that nano preparation technology could effectively improve the bioavailability and targeting treatment of anticancer tea components. In addition, in the past decade, patents on tea and natural anticancer agents in tea were relatively rich, among which pharmaceutic preparation patents were the majority, and tea polyphenols were the main ones.This paper concluded that there are many kinds of natural anticancer agents in tea, and the anticancer mechanism is complex. Further research on the structural modification, drug delivery system and toxicological evaluation of relevant anticancer active components can be carried out. In general, tea components as new anticancer substances have a certain potential for development. In addition, future research can be focused on the comprehensive study of the structure-activity relationship, the in-depth study of the molecular mechanism, the in-depth understanding of the anticancer effects in vivo, and the verification of large-scale production.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Krim完成签到 ,获得积分10
1秒前
隔壁的镇长完成签到,获得积分10
3秒前
yys发布了新的文献求助10
4秒前
浮生若梦完成签到,获得积分10
5秒前
黑球完成签到,获得积分10
5秒前
燕晓啸完成签到 ,获得积分0
5秒前
epmoct完成签到 ,获得积分10
6秒前
一叶舟完成签到,获得积分10
8秒前
李健应助黑球采纳,获得10
9秒前
伴夏完成签到 ,获得积分10
14秒前
徐悦完成签到,获得积分10
19秒前
19秒前
cripple完成签到,获得积分10
24秒前
wowser发布了新的文献求助10
26秒前
整齐的大开完成签到 ,获得积分10
26秒前
涨芝士完成签到 ,获得积分10
29秒前
悬崖茶杯完成签到 ,获得积分10
30秒前
wowser完成签到,获得积分10
34秒前
科研通AI2S应助辛勤寻琴采纳,获得10
37秒前
philophysics关注了科研通微信公众号
38秒前
LISHO完成签到 ,获得积分10
38秒前
panpan111完成签到,获得积分10
44秒前
可爱的紫菜完成签到 ,获得积分10
50秒前
luckweb完成签到,获得积分10
54秒前
李爱国应助i好运采纳,获得10
56秒前
小墨墨完成签到 ,获得积分10
1分钟前
研友_851KE8发布了新的文献求助10
1分钟前
twelveyears完成签到 ,获得积分10
1分钟前
1分钟前
务实青筠完成签到 ,获得积分10
1分钟前
nine2652完成签到 ,获得积分10
1分钟前
跳跃完成签到,获得积分10
1分钟前
Lyann完成签到,获得积分10
1分钟前
淀粉肠完成签到 ,获得积分10
1分钟前
研友Bn完成签到 ,获得积分10
1分钟前
fanzi完成签到 ,获得积分10
1分钟前
研友_851KE8完成签到,获得积分10
1分钟前
laogao完成签到,获得积分10
1分钟前
袁青欣完成签到 ,获得积分10
1分钟前
Albert完成签到,获得积分10
1分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052652
求助须知:如何正确求助?哪些是违规求助? 2709874
关于积分的说明 7418298
捐赠科研通 2354492
什么是DOI,文献DOI怎么找? 1246104
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921