纳米医学
生物相容性
纳米技术
纳米颗粒
材料科学
光热治疗
吸光度
生物分子
化学
色谱法
冶金
作者
Alessio Carmignani,Matteo Battaglini,Edoardo Sinibaldi,Attilio Marino,Veronica Vighetto,Valentina Cauda,Gianni Ciofani
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-01-14
卷期号:5 (1): 1702-1713
被引量:25
标识
DOI:10.1021/acsanm.1c04536
摘要
Polydopamine (PDA) is a polymer that derives from the self-polymerization of the biomolecule dopamine. It can be easily synthesized to obtain spherical nanoparticles (PDNPs), tunable in terms of size, loaded cargo, and surface functionalization. PDNPs have been increasingly attracting the attention of the research community due to their elevated versatility in the biomedicine field, for their excellent ability to encapsulate drugs, to convert near-infrared (NIR) radiation into heat, and to act as an antioxidant agent. Size is an important aspect to be considered, especially concerning the specific intended field of application. This work aims at investigating how changes in the size of PDNPs affect the nanoparticle properties relevant for biomedical applications, especially focusing on cancer nanomedicine. A library of differently sized PDNPs (from 145 to 957 nm) has been obtained by varying the ammonia/dopamine molar ratio during the synthesis procedure, and detailed characterization in terms of biocompatibility, cell internalization, antioxidant capacity, and photothermal conversion has been carried out. Experiments showed that nanoparticles with a larger diameter display higher NIR absorbance, superior resistance to degradation, and higher photothermal conversion capacity (the latter confirmed by a mathematical model). On the other hand, a reduction in diameter size induces both improved antioxidant properties and enhanced cellular uptake. Herein, we provide a useful tool, allowing one to choose the proper size of PDNPs tailored for specific biomedical applications.
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