生物催化
生化工程
范围(计算机科学)
化学
持续性
级联
蛋白质工程
纳米技术
酶催化
酶
生物技术
组合化学
催化作用
计算机科学
有机化学
材料科学
工程类
生物
反应机理
生态学
色谱法
程序设计语言
作者
Chihui An,Kevin M. Maloney
标识
DOI:10.1016/j.cogsc.2022.100591
摘要
Cascade reactions have been widely recognized to cut costs, decrease solvent usage, and reduce cycle times in chemical processes. Recently, biocatalytic cascades have altered how we design synthetic routes to complex molecules to achieve sustainable commercial processes for pharmaceutical, agricultural, and fine chemical industries. With advancements in protein engineering and an increase in the number of enzyme classes available to chemists, industrial and academic groups alike have endeavored to expand the scope of biocatalysis from single reactions to multi-enzyme cascades to rapidly build complex molecular structures. Recent reports have drawn inspiration from biosynthetic pathways and have applied engineered enzymes to in vitro enzymatic cascades. Furthermore, combining transition-metal catalysis and enzymes in one-pot chemoenzymatic cascades likewise serves to broaden the scope of biocatalysis, enabling traditional chemical reactions to be performed under mild aqueous conditions. In this article, we review recent biocatalytic and chemoenzymatic cascades from 2019 to 2021.
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