SYNERGISTIC EFFECT OF PROSTAGLANDIN E1 ON NORADRENALINE INDUCED LIPOLYSIS IN ADIPOSE TISSUE FROM HYPOTHYROID SUBJECTS

The lipolytic action of noradrenaline in vitro is markedly reduced in subcutaneous adipose tissue of hypothyroid subjects. This is due to an increased responsiveness of the alpha adrenergic receptors to noradrenaline, resulting in the suppression of the beta receptor mediated lipolytic effect of the hormone.