壳聚糖
透明质酸
金黄色葡萄球菌
抗菌活性
离子强度
粘附
逐层
化学
铜绿假单胞菌
润湿
离子键合
核化学
图层(电子)
材料科学
化学工程
细菌
有机化学
生物
水溶液
复合材料
离子
工程类
遗传学
作者
V. F. Nascimento,Carla Giometti França,Jacobo Hernández‐Montelongo,Daisy Machado,Marcelo Lancellotti,M. A. Cotta,Richard Landers,Marisa Masumi Beppu
标识
DOI:10.1016/j.eurpolymj.2018.09.038
摘要
Hyaluronic acid (HA)/chitosan (CHI) films were assembled by LbL using different conditions of pH and ionic strength (IS) in order to obtain stable surfaces to avoid the adhesion and proliferation of Pseudomonas aeruginosa and Staphylococcus aureus. The results showed that pH and IS were key synthesis variables for obtaining different features, such as wettability, thickness and the availability of functional groups. The antibacterial effect was more effective against S. aureus with a reduction of approximately 3, 4, and 1.5 log reduction after 4, 8 and 24 h of culture time, respectively. In the case of P. aeruginosa, the films presented a lower bacterial reduction: 1 log reduction in times evaluated. In conclusion, the results of the antibacterial effect against S. aureus after 24 h, suggest that the HA/CHI films assembled by LbL can protect several substrates, such as biomedical devices, against bacterial proliferation.
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