溶解度
无定形固体
埃法维伦兹
喷雾干燥
材料科学
化学工程
色散(光学)
拉曼光谱
化学
有机化学
光学
人类免疫缺陷病毒(HIV)
病毒载量
工程类
物理
家庭医学
医学
抗逆转录病毒疗法
作者
Bhianca Lins de Azevedo Costa,Martial Sauceau,Romain Sescousse,Maria Inês Ré
标识
DOI:10.4995/ids2018.2018.7871
摘要
Amorphous solid dispersions (ASDs) refers to drug - carrier systems, where the drug is dispersed in the carrier at a molecular level. In this work, ASDs were formulated by spray drying. The aim was to achieve high drug loads of an amorphous hydrophobic drug (Efavirenz - EFV) in the carrier Soluplus®. Solid state characterizations (mDSC, XRPD, DVS, Raman, SEM, stability and solubility studies) were done. EFV amorphisation in ASDs (20 to 85% EFV loads) resulted in improved drug solubility compared to unprocessed EFV crystals and tendency of properties evolution over time for ASDs with EFV loads higher than 70 wt%. Keywords: amorphous solid dispersion, spray drying, high drug loading, soluplus, efavirenz.
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