透明质酸
胶质瘤
缺氧(环境)
肿瘤微环境
肿瘤缺氧
磁共振成像
纳米颗粒
材料科学
癌症研究
化学
纳米技术
放射治疗
医学
内科学
氧气
肿瘤细胞
有机化学
放射科
解剖
作者
Chaoping Fu,Xiaohui Duan,Minghui Cao,Shuhan Jiang,Xiaohua Ban,Na Guo,Fang Zhang,Jiaji Mao,Ting Huyan,Jun Shen,Liming Zhang
标识
DOI:10.1002/adhm.201900047
摘要
Abstract Manganese dioxide (MnO 2 )‐based nanoparticles are a promising tumor microenvironment‐responsive nanotheranostic carrier for targeted magnetic resonance imaging (MRI) and for alleviating tumor hypoxia. However, the complexity and potential toxicity of the present common synthesis methods limit their clinical application. Herein, multifunctional hyaluronic acid‐MnO 2 nanoparticles (HA‐MnO 2 NPs) are synthesized in a simple way by directly mixing sodium permanganate with HA aqueous solutions, which serve as both a reducing agent and a surface‐coating material. The obtained HA‐MnO 2 NPs show an improved water‐dispersibility, fine colloidal stability, low toxicity, and responsiveness to the tumor microenvironment (high H 2 O 2 and high glutathione, low pH). After intravenous injection, HA‐MnO 2 NPs exhibit a high imaging sensitivity for detecting rat intracranial glioma with MRI for a prolonged period of up to 3 d. These nanoparticles also effectively alleviate the tumor hypoxia in a rat model of intracranial glioma. The downregulation of VEGF and HIF‐1α expression in intracranial glioma validates the sustained attenuation effect of HA‐MnO 2 NPs on tumor hypoxia. These results show that HA‐MnO 2 NPs can be used for sensitive, targeted MRI detection of gliomas and simultaneous attenuation of tumor hypoxia.
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