生物污染
生物电子学
佩多:嘘
导电聚合物
聚合物
材料科学
蛋白质吸附
高分子化学
化学工程
共聚物
单体
甲基丙烯酸酯
噻吩
电化学
基质(水族馆)
介电谱
化学
生物传感器
纳米技术
有机化学
电极
膜
复合材料
工程类
地质学
物理化学
海洋学
生物化学
作者
Tatsuro Goda,Yuji Miyahara
出处
期刊:Langmuir
[American Chemical Society]
日期:2018-07-13
卷期号:35 (5): 1126-1133
被引量:35
标识
DOI:10.1021/acs.langmuir.8b01492
摘要
Conferring antifouling properties can extend the use of conducting polymers in biosensors and bioelectronics under complex biological conditions. On the basis of the antifouling properties of a series of zwitterionic polymers, we synthesized new thiophene-based compounds bearing a phosphorylcholine, carboxybetaine, or sulfobetaine pendant group. The monomers were synthesized by a facile reaction of thiol-functionalized 3,4-ethylenedioxythiophene with zwitterionic methacrylates. Electrochemical copolymerization was performed to deposit zwitterionic poly(3,4-ethylenedioxythiophene) (PEDOT) films with tunable conducting and antifouling properties on a conducting substrate. Electrochemical impedance spectroscopy showed that the conductivity and capacitance decreased with increasing zwitterionic content in the films. Protein adsorption and cell adhesion studies showed the effects of the type and content of zwitterions on the antifouling characteristics. Optimization of the electrodeposition conditions enabled development of both conducting and antifouling polymer films. These antifouling conjugated functional polymers have promising applications in biological environments.
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