Selective Functionalization of Calix[6]arenes at the Upper Rim

All articles of this category Methylation of partially O -benzylated p-tert -butylcalix[6]arenes followed by hydrogenolysis constitutes an efficient method for the preparation of partially O -alkylated Calix[6]arenes in gram amounts, without adhering to column chromatography separations. Selective de- tert -butylation followed by halogenation, or ipso -nitration of these precursors affords Calix[6]arenes containing bromo- or nitrosubstituents, respectively, at precise positions of the upper rim.