Voluntary exercise protects against ulcerative colitis by up‐regulating glucocorticoid‐mediated PPAR‐γ activity in the colon in mice

These findings suggest that prior voluntary exercise suppresses the expression of pro-inflammatory cytokines in the colon in response to inflammatory challenge by up-regulating glucocorticoid-mediated PPAR-γ activity, contributing to protection against the development of ulcerative colitis.