The skin irritation test of the preparation for external application in hospital

OBJECTIVE To investigate the skin irritation test of 18 preparation(NSP) for external use in hospital for safety assessment and rational use of the drugs.METHODS Apply the preparation to rabbits'skin in a short time, and study the skin irritation and relevant adverse drug reactional within the fixed time.RESULTS 2 drugs showed moderate skin irritation,8 slight irritation and 8 no irritation.CONCLUSIONS It is suggested that preparation with skin irritation should be readjusted for decreasing its adverse reactions,and not used on the damaged skin.