Computational Fluid Dynamics is applied to the design of centrifugal pump impeller,which takes the flow field in impeller vane as the research object and adopts unstructured grid.Based on Navier-Stokes equation and k-e turbulence model,the flow field of centrifugal pump is calculated.According to the results,we can redesign and optimize the pump impeller by changing the intake angle of impeller and remodeling the leaf blade shape.It is proved that the modified impeller has a better match in flow characteristic than the old impeller.