Development of catheter with slow-release amikacin and the releasing research in vitro

Objective To develop the catheter with slow-release amikacin for decreasing the catherter-associated urinary tract infection(CAUTI).Methods Taking chitosan as a carrier,the amikacin was added to the surface of catheters.The density of amikacin in leach liquor,the element components and the antibacterial activity of amikacin in the membrane were determined by spectrophotometric method,energy spectrum analysis technology(EDAX) and direct antibacterial experiment respectively.Results The antibacterial amikacin was added to the the surface of catheters by the method described in this paper.Meanwhile,the antibacterial activity of amikacin was maintained.The slow-release time of amikacin exceeded 15 days.Conclusion The method described in the paper can be used for developing the catheter with slow-release amikacin.The catheter can also be used to prevent the CAUTI.