Probiotics Cross Talk with Multi Cell Signaling in Colon Carcinogenesis

Probiotics has been considered as health beneficial micro-organism which is well documented for their role in maintaining homeostasis. The possible mechanisms in control of colon cancer are still in sprouting stage and need to explore it. Genetic events lead to epigenetic changes in cell signaling pathways causing colon cancer by cell proliferation and inhibition of apoptosis. Reported evidence supports that probiotics could be able to inhibit colon cancer by inhibition of cell proliferation by interaction with β-catenin/Wnt-pathway, and arachidonic acid components such as cyclooxygenase-2. In this review, we attempted to summarize how probiotics might play beneficial roles in regulating or/ and modulating colon cancer cell signaling.