光热治疗
聚吡咯
透明质酸
光动力疗法
纳米颗粒
纳米技术
材料科学
化学
医学
聚合物
聚合
复合材料
有机化学
解剖
作者
Tuan Hiep Tran,Hanh Thuy Nguyen,Thi Thu Phuong Tran,Sae Kwang Ku,Jee‐Heon Jeong,Han‐Gon Choi,Chul Soon Yong,Jong Oh Kim
出处
期刊:Nanomedicine
日期:2017-06-01
卷期号:12 (12): 1511-1523
被引量:28
标识
DOI:10.2217/nnm-2016-0438
摘要
To develop a nanoparticle-based platform using polypyrrole and IR-780 for effective combined photothermal and photodynamic therapy.IR-780 was loaded in a poly(lactic-co-glycolic acid) core, decorated with polypyrrole shells and hyaluronic acid (IPPH). Physicochemical properties and in vitro and in vivo anticancer effects of these nanoparticles were evaluated.The resulting IPPHs were spherical, small and negatively charged. Under near-infrared laser irradiation, the IPPHs generated reactive oxygen species and heat and synergistically improved therapeutic efficacy. The antitumor effects were confirmed by in vitro cellular reactive oxygen species detection and cytotoxicity assays, and in vivo in a xenograft tumor model, with no damage to body organs.Our results indicate the potential of applying IPPH in oncology nanomedicine.
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