纳米传感器
费斯特共振能量转移
量子点
检出限
DNA
信号(编程语言)
荧光
DNA甲基转移酶
甲基转移酶
化学
生物分子
生物物理学
纳米技术
材料科学
物理
计算机科学
生物
生物化学
色谱法
光学
甲基化
程序设计语言
作者
Fei Ma,Wenjing Liu,Bo Tang,Chunyang Zhang
摘要
We develop a single quantum dot (QD)-based nanosensor for the signal-on detection of DNA methyltransferase (MTase). By integration of single-molecule counting with the QD-based fluorescence resonance energy transfer (FRET), the proposed nanosensor can sensitively detect DNA MTase with a detection limit of as low as 0.002 U mL-1, and it can be further applied for inhibitor screening and accurate detection of DNA MTase in complex biological samples.
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