颞叶
脑回
梭状回
癫痫
额上回
心理学
颞下回
前颞叶切除术
医学
内科学
核医学
神经科学
认知
作者
Shuhua Ren,Qi Huang,Wei Bao,Donglang Jiang,Jianfei Xiao,Junpeng Li,Fang Xie,Yihui Guan,Rui Feng,Fang Hua
出处
期刊:Neuroscience
[Elsevier]
日期:2021-12-01
卷期号:478: 39-48
被引量:4
标识
DOI:10.1016/j.neuroscience.2021.10.012
摘要
Drug-resistant temporal lobe epilepsy (TLE) is a potential candidate for surgery; however, nearly one-third subjects had a poor surgical prognosis. We studied the underlying neuromechanism related to the surgical prognosis using graph theory based on metabolic brain network. Sixty-four unilateral TLE subjects with preoperative 18F-fluorodeoxyglucose (FDG) PET scanning were retrospectively enrolled and divided into Ia (Engel class Ia, n = 32) and non-Ia (Engel class Ib-IV, n = 32) groups according to more than 3-year follow-up after unilateral anterior temporal lobectomy (ATL). The metabolic brain network was constructed and the changed metabolic connectivity of Ia and non-Ia was detected compared with 15 matched healthy controls (HCs). Further, the network properties, including small-worldness and global efficiency, were calculated and hub nodes were also identified for the 3 groups respectively. Non-Ia group exhibited increased connectivity between contralateral fusiform gyrus and contralateral lingual gyrus; while Ia showed decreased connectivity mainly among bilateral frontal, temporal and parietal cortex. Graph theoretical analysis revealed that non-Ia group showed increased small-worldness (35%
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