细胞器
细胞内
功能(生物学)
细胞生物学
生物
线粒体
粒体自噬
细胞
线粒体融合
自噬
线粒体DNA
遗传学
细胞凋亡
基因
作者
Zuzana Nahácka,Renata Zobalova,Maria Dubisova,Jakub Rohlena,Jiřı́ Neužil
标识
DOI:10.1080/10409238.2021.1925216
摘要
Mitochondria are organelles present in most eukaryotic cells, where they play major and multifaceted roles. The classical notion of the main mitochondrial function as the powerhouse of the cell per se has been complemented by recent discoveries pointing to mitochondria as organelles affecting a number of other auxiliary processes. They go beyond the classical energy provision via acting as a relay point of many catabolic and anabolic processes, to signaling pathways critically affecting cell growth by their implication in de novo pyrimidine synthesis. These additional roles further underscore the importance of mitochondrial homeostasis in various tissues, where its deregulation promotes a number of pathologies. While it has long been known that mitochondria can move within a cell to sites where they are needed, recent research has uncovered that mitochondria can also move between cells. While this intriguing field of research is only emerging, it is clear that mobilization of mitochondria requires a complex apparatus that critically involves mitochondrial proteins of the Miro family, whose role goes beyond the mitochondrial transfer, as will be covered in this review.
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