Low Levels of Klotho are Associated with Intracranial Vascular Calcification in Patients with CKD

We read with interest the article recently published by Vinters et al.1 The authors analyzed autopsy brains from patients with chronic kidney disease (CKD) and observed a high prevalence of atherosclerosis and arteriolosclerosis. In addition, the authors call attention to the severe calcification finding. Indeed, vascular calcification is a highly prevalent condition in both situations CKD2 and aging,3 and, as stated by the authors, this makes it difficult to characterize which neuropathologic feature is derived from each clinical situation.