[ZHU Lian's type-Ⅰ inhibition acupuncture combined with Zhuang medicinal thread moxibustion for acute herpes zoster].

To observe the clinical efficacy of ZHU Lian's type-Ⅰ inhibition acupuncture combined with Zhuang medicinal thread moxibustion for acute herpes zoster (HZ), and explore the possible analgesic mechanism.Sixty-six patients with acute HZ were randomly divided into an observation group (33 cases, 1 case dropped off) and a control group (33 cases, 1 case dropped off). The patients in the control group were treated with valaciclovir hydrochloride tablets, mecobalamin tablets and vitamin B1 tablets for 14 days. The patients in the observation group were treated with ZHU Lian's type-Ⅰ inhibition acupuncture and Zhuang medicinal thread moxibustion. ZHU Lian's type-Ⅰ inhibition acupuncture was given at ashi points (around herpes site), Qimen (LR 14), Geshu (BL 17), Quchi (LI 11), Xuehai (SP 10) and Neiguan (PC 6); Zhuang medicinal thread moxibustion was given at Changzi point, Kuihua point, Xionglongji point, Zhuang medicine Jiaji points; both the treatment was given once every other day for 14 days. The symptom improvement (blister stopping time, scab forming time, scab removing time) in the two groups were observed. The pain visual analogue scale (VAS) score and serum levels of interleukin (IL)-6, IL-8, substance P (SP) in the two groups before and after treatment were compared. The clinical efficacy of the two groups and the recurrence rate of neuralgia 1, 2, 3 months after treatment were evaluated.The blister stopping time, scab forming time and scab removing time in the observation group were earlier than those in the control group (P<0.05). Compared before treatment, VAS scores and serum levels of IL-6, IL-8 and SP in the two groups were decreased after treatment (P<0.05), and those in the observation group were lower than those in the control group (P<0.05). The total effective rate in the observation group was 96.9% (31/32), which was higher than 84.4% (27/32) in the control group (P<0.05). The recurrence rates of neuralgia 1, 2, 3 months after treatment in the observation group were 9.7%, 6.5%, 3.2%, which were lower than 29.6%, 22.2%, 14.8% in the control group (P<0.05).The ZHU Lian's type-Ⅰ inhibition acupuncture combined with Zhuang medicinal thread moxibustion have better analgesic effect and lower recurrence rate of neuralgia in patients with acute HZ, and this effect might be related to the reduction of serum IL-6, IL-8 and SP levels.目的：观察朱琏抑制Ⅰ型针法结合壮医药线点灸治疗急性期带状疱疹（HZ）的临床疗效，并探讨可能的镇痛机制。方法：将66例急性期HZ患者随机分为观察组（33例，脱落1例）和对照组（33例，脱落1例）。对照组予以口服盐酸伐昔洛韦分散片、甲钴胺片及维生素B1片治疗，连续服用14 d。观察组采用朱琏抑制Ⅰ型针法结合壮医药线点灸治疗，朱琏抑制Ⅰ型针法穴取阿是穴（疱疹部位及周围）、期门、膈俞、曲池、血海、内关，壮医药线点灸穴取长子穴、葵花穴、胸龙脊穴、壮医夹脊穴，均隔日治疗1次，共治疗14 d。观察两组患者的症状改善情况（止疱时间、结痂时间、脱痂时间），比较两组患者治疗前后疼痛视觉模拟量表（VAS）评分及血清白细胞介素（IL）-6、IL-8、P物质（SP）水平，评定两组临床疗效和治疗后1、2、3个月有效患者的神经痛复发率。结果：观察组止疱时间、结痂时间、脱痂时间均早于对照组（P<0.05）。与治疗前比较，两组治疗后VAS评分及血清IL-6、IL-8、SP水平均降低（P<0.05），且观察组低于对照组（P<0.05）。观察组总有效率为96.9%（31/32），高于对照组的84.4%（27/32，P<0.05）。治疗后1、2、3个月，观察组的神经痛复发率分别为9.7%、6.5%、3.2%，均低于对照组的29.6%、22.2%、14.8%（P<0.05）。结论：朱琏抑制Ⅰ型针法结合壮医药线点灸治疗急性期HZ镇痛效果较好、神经痛复发率低，可能与降低血清IL-6、IL-8、SP水平有关。.